UNIT I:INTRODUCTION TO COMPUTATIONAL MOLECULAR BIOLOGY
Introduction to active areas of research in Computational Molecular Biology, Functional Genomics, Comparative Genomics, Dynamic Programming, Graphical representation of biochemical systems, S-systems equations, steady state analysis, Model refinements
UNIT II : GENOMICS
DNA Sequence assembly and gene identification. Homology based gene prediction.Gene expression profiling,Identification of SNPs,SNP
Arrays,Role f SNP’s in Pharmacogenomics,other applications, Methods of studying gene expression, EST approach,Human Genome Project
UNIT-III MICRO ARRAYS
Understanding microarray data,normalising microarray
data,detecting differential gene expression,Correlation of gene expression data
to biological process and Computational anaysis tool
UNIT IV: PROTEOMICS I
Introduction to proteins. Protein identification, structure and function determination. Structure comparison methods. Prediction of secondary structure from sequence.
UNIT V: PROTEOMICS II
Protein homology modeling, Protein threading. Protein ab initio structure prediction. Protein design emphasis on structural Bioinformatics.
UNIT VI: TAXONOMY AND PHYLOGENY
Basic concepts in systematics, systematics,Taxonomy and Phylogeny,Nature of data used in
taxonomy and phylogeny,Molecular evolution, Definition and description of Phylogenetic trees and types of trees
UNIT-VII: DENDROGRAMS
Dendograms and its interpretation
UNIT-VIII: DRUG DESIGN
Drug discovery process,role of bioinformatics in drug
design,target identification and validation,lead optimization and validation.
TEXT BOOKS:
1. David W Mount. Bioinformatics- Sequence and genome analysis. CSHL Press.
2. Jonathan Pevsner . Bioinformatics and Functional Genomics. A Jhon Wiely & Sons, Inc., Publication
3. E.O.Voit Computational Analysis of Biochemical systems, Cambridge University Press 2000.
REFERENCES:
1. Moody P C E and A J Wilkinson. Protein Engineering. IRL Press.
2. Creighton T E, Proteins. Freeman W H. Second edition 1993.
3. Journal BIOINFORMATICS (Oxford University).
4. BRANDOND TOOZE – Proteomics